Wow, looking for supporting references for a project I’m working on related to lateral column connectivity and “voting” I stumbled upon this researcher you should check out Anna Wang Roe.
She’s a huge proponent of cortical column level mapping. Over many years they’ve developed an experimental technique INS-fMRI where they can excite a single cortical column with an infrared pulse through a fiber optic cable (such as the center of a pinwheel!), and then simultaneously use UHF 7 Tesla MRI to get column-and-layer resolved signals of excitation of connected columns. Wild!
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I went thru some of her papers, pretty neat stuff. Seems like she spent the pandemic honing her apparatus to enable these studies, and results are gradually coming out.
Also found a very interesting 2021 keynote from her:
…She was into columnar heterarchy before it was even cool! 
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A single one???
I’m 100% sure that voting breakdown cause beta amyloid build up
Voting breakdown= too much hcn1 utilized to maintain stability of pnns stability in spite of environmental excitation
Look for cortical column-cerebellum correspondence in neural correlates (topology in physical substrate not just in TDA of readings) for areas that are limited in their incorporated “weight” at thalamic classification/sorting.
Proteoglycans will be higher in correlate regions of cerebellum with cortical columns.
Much love from NC.
Ethan
@integratedview (X)
The thalamus is Magnitude first, horizontal or vertical after. See recent work on optical translation. Should be same for all. Proteoglycans set filter for what’s “allowed” to be included regardless of local activity. Likely just higher threshold. Would be interesting to find out how much pg density = full silence
Like, how many ncc systems have to be silenced to limit 1 cortical column from reporting? How many can be silenced at one time? Etc. likely a key to translating nccs to subjective perception.
